Senigra Tablets – 50mg & 100mg Strengths

Description

S-fil works by inhibiting the enzyme Phosphodiesterase type 5 (PDE5). Inhibition of PDE5 results in the accumulation of cyclic GMP (cGMP), a chemical that relaxes the smooth muscle walls of blood vessels (vasodilation).

• For Erectile Dysfunction: During sexual stimulation, this vasodilation increases blood flow to the penis, which is necessary to achieve an erection. It is crucial to note that sexual stimulation is mandatory for S-fil to cause an erection.   
• For Pulmonary Arterial Hypertension: It relaxes the pulmonary vasculature, reducing blood pressure in the lungs and decreasing strain on the heart.   

Dosage and Administration

S-fil should only be taken according to the specific directions provided by your doctor.   

• Dosage: Senigra (50mg or 100mg) should not be taken more than once per day.
  • For ED: The usual starting dose is 50mg, taken as needed . Based on efficacy and tolerability, the dose may be increased to a maximum of 100mg or decreased to 25mg under the guidance of a physician .
• Timing: Take the tablet approximately 30 minutes to 1 hour before sexual activity. The effect can last up to 4 hours.   
• Food and Drug Interactions:
  • Taking S-fil with high-fat meals may delay the onset of action (peak plasma levels can be delayed from 30 minutes up to 120 minutes).   
  • Avoid Alcohol, as it may increase the risk of dizziness and difficulties achieving an erection.   
  • Grapefruit juice should be avoided as it can elevate S-fil levels in the body, increasing the risk of side effects.   

Mandatory Warnings and Contraindications

This section is vital for patient safety and must be clearly visible.

Absolute Contraindications (Strictly Forbidden)

S-fil must NEVER be used in combination with the following, as the interaction can cause a life-threatening drop in blood pressure (Severe Hypotension):

1. Nitrates: Medications used for chest pain (Angina), such as Nitroglycerin or Isosorbide Mononitrate, or recreational nitrates (“poppers”).   
2. Guanylate Cyclase Stimulators: Medications like Riociguat or Vericiguat.   
3. Allergy: Known hypersensitivity to S-fil or any component of the formulation.   
4. Vision Issues: History of Non-arteritic Ischemic Optic Neuropathy (NAION) or inherited degenerative retinal disorders .

Serious Warnings (Immediate Medical Attention Required)

Stop taking Senigra and seek emergency medical care immediately if any of the following symptoms occur :   

• Priapism (Prolonged Erection): An erection lasting longer than 4 hours, which can cause permanent damage to the penis if untreated.   
• Sudden Sensory Loss: Sudden loss or decrease in hearing (sometimes with tinnitus and dizziness), or sudden loss of vision/blurred vision .
• Cardiac Events: Chest pain, severe dizziness, fainting, or shortness of breath.   
• Severe Allergic Reaction: Swelling of the face, lips, throat, or tongue; difficulty breathing; or severe rash/hives.   

Essential Safety Warnings and Precautions for Senigra

Side Effects

S-fil side effects are generally mild and may decrease as the body adjusts.   

Common Side Effects (Affecting more than 1 in 100 people)

• Headache (Rest and drink fluids. Headaches usually subside after the first week).   
• Flushing (Feeling of warmth, redness in the face/neck).   
• Nasal Congestion (Stuffy nose).   
• Nausea or Indigestion (May help to take it after a meal or snack).   
• Dizziness (Do not drive or operate machinery if you feel dizzy).   
• Changes in vision (e.g., a slight blue tinge to objects, sensitivity to light)

Less Common Side Effects

Less frequently reported effects include vomiting, sleep disturbances, muscle or back pain, rash/itching, and rapid heartbeat or low blood pressure.